Belly or duodenal ulcer. If you have a tummy ulcer or duodenal ulcer, prednisone could ensure it is worse. Getting prednisone using an NSAID (ache reliever) such as ibuprofen may also increase your risk of developing or worsening an ulcer. When you've got one of these ulcers, talk to your medical doctor about no matter if prednisone is ideal for yo